Apoquel (oclacitinib) is a fast-acting prescription medication that relieves itching and inflammation in dogs with allergies. It works by blocking enzymes called Janus kinases (JAKs) that trigger the itch-scratch cycle, often providing relief within 24 hours.
Apoquel (oclacitinib) is a fast-acting prescription medication that relieves itching and inflammation in dogs with allergies. It works by blocking enzymes called Janus kinases (JAKs) that trigger the itch-scratch cycle, often providing relief within 24 hours.
• Apoquel targets JAK enzymes to stop itching at the source
• Most dogs experience noticeable relief within 4 to 24 hours after starting treatment
• Approved for dogs 12 months and older; requires a veterinary prescription
• Can be used short-term or long-term under veterinary supervision
The severity of a dog’s allergy symptoms tends to vary depending on the amount of exposure to the allergens and usually worsen with time as dogs age. Although treatment can help reduce the dog’s discomfort, allergies cannot be cured. If your dog is itching, chewing, licking, etc., consult with a vet. Other conditions like infections or parasites can cause itching too, so pinpointing the exact cause can take some patience and testing.
Otis specifically offers convenient and accessible care online with veterinarians specialized in treating allergies. Otis’ vets can diagnose, recommend treatment, and prescribe appropriate medications like Apoquel via same-day virtual visits - so you can skip the long waits and stressful car rides.
Apoquel is an orally administered tablet that reduces itching and inflammation associated with allergic dermatitis in dogs. Unlike steroids, it doesn't suppress the entire immune system—it selectively blocks JAK1 and JAK3 enzymes responsible for sending "itch signals" between cells. Through this mechanism Apoquel provides relief from itching and inflammation with fewer side effects from steroids, and has been successfully used for short-term flare-ups and long-term allergy management.
Your vet will likely start your dog on twice-daily doses for about two weeks to get symptoms under control, then taper down to once a day for ongoing management. Note that Apoquel is not recommended for puppies less than one year old, and should be avoided in pregnant or nursing dogs.
Generally, Apoquel is well tolerated by dogs, but like most medications, does carry some risks. The most frequently reported issues are digestive upset (like an upset stomach or loose stools), decreased appetite, and lethargy. These tend to be mild and often improve when you give the medication alongside food.
Apoquel should not be used in dogs with a history of cancer, serious infections or demodectic mange. Report any new skin growths to your vet immediately. Because Apoquel works by suppressing part of the immune system, dogs taking it are considered mildly immunosuppressed.
Additionally, while Apoquel can eliminate the itching associated with allergies, dogs suffering from allergies often develop secondary issues such as bacterial skin infections and/or chronic ear problems that will also require treatment. In addition to eliminating the itching, a vet may recommend additional treatments to address secondary issues.
Consult a vet if your dog is:
• Scratching, licking, or chewing excessively
• Exhibiting redness, swelling, or broken skin
• Developing recurring ear infections or hot spots
Your vet will be able to determine if Apoquel is an appropriate medication for your dog or if additional treatments such as medicated shampoos, antibiotics or fish oil supplements will be necessary to address your dog’s allergies.
For specialized allergy care without long clinic waits, Otis offers online veterinary consultations focused on dog itch and allergies - with personalized treatment plans from home.
Yes, depending on your state. Otis vets specialize in dog allergies and can prescribe Apoquel through a virtual consultation where regulations allow. They offer same-day appointments, so you can skip the long waits and car trips to the clinic.
Apoquel doesn't work for every dog. Your vet may recommend combination therapies or alternatives like Cytopoint.
Yes. It's approved for both short and long-term use, with routine monitoring recommended for extended treatment.
Apoquel generally has fewer systemic side effects because it targets specific pathways rather than broadly suppressing immunity. Your vet can help determine the best option for your dog.
Most dogs show reduced itching within 4 hours, with significant improvement by 24 hours.
